Madecassoside, asiaticoside, and why Korea’s signature healing ingredient actually works.
If you’ve spent any time in the K-beauty aisle, you’ve seen “cica” everywhere. Cica creams, cica serums, cica everything. The ingredient behind it all is centella asiatica — a plant that’s been used in Korean and Ayurvedic medicine for centuries. But not all cica products are equal, and the difference comes down to understanding what’s actually doing the work.
Centella asiatica’s power comes from four specific compounds: madecassoside (anti-inflammatory, barrier repair), asiaticoside (collagen synthesis, wound healing), madecassic acid (tissue regeneration), and asiatic acid (antioxidant, firming). These four compounds work synergistically. Products that contain the whole centella extract get all four. Products that isolate just one — like madecassoside alone — miss the synergy. This is why SKIN1004’s 96% centella extract outperforms products with isolated derivatives.
Insight
Centella asiatica is called “tigre grass” in many Asian markets because legend holds that wounded tigers would roll in centella patches to heal themselves. The wound-healing properties aren’t legend though — they’re clinically documented.
Centella has been used in Korean herbal medicine for centuries, but the modern K-beauty cica boom started around 2017-2018. SKIN1004 launched its Madagascar Centella Ampoule with 96% centella extract — essentially pure centella in a bottle. Purito followed with its Centella line. Dr. Jart+ brought cica to the Western market with Cicapair. Today, nearly every major K-beauty brand has a cica line. The ingredient went from traditional remedy to global skincare staple in under a decade.
Here’s where most consumers get misled. A product that lists “centella asiatica extract” as the first ingredient (like SKIN1004 at 96%) is fundamentally different from a product that lists it at position 15 on the ingredient list. Position on the INCI list reflects concentration. If centella is buried behind water, glycerin, dimethicone, and twelve other ingredients, you’re getting a trace amount with a “cica” label. Always check where centella appears on the ingredient list.

SKIN1004
Centella Asiatica Ampoule
$17
vs $28
SKIN1004 Madagascar Centella Ampoule ($18) — 96% centella extract, the purest option available. Minimal formula, maximum concentration. The benchmark for cica products. Purito Centella Unscented Recovery Cream ($16) — centella in a soothing cream format with panthenol and madecassoside. Fragrance-free, designed for sensitive and reactive skin. Purito Centella Unscented Serum ($16) — a lightweight centella serum that layers beautifully under moisturizer. Great for adding centella to any existing routine.

Purito
Centella Recovery Cream
$19
vs $42

Purito
Centella Unscented Serum
$22
vs $30
Centella asiatica isn’t a trend ingredient — it’s an established active with centuries of traditional use and modern clinical backing. The K-beauty brands that built their identities around it (SKIN1004, Purito) deliver it at concentrations that actually work. When you see “cica” on a label, check the ingredient list. Concentration is the difference between a centella product and a centella-marketed product.